产品货号：
GS4382
中文名称：
重组人Angiostatin
英文名称：
Recombinant Human Angiostatin
产品规格：
10μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 29.7 KDa,a single non-glycosylated polypeptide chain containing 259 amino acids.
储存条件：冷冻（-20℃）
概述
Angiostatin,is a~30kDafragment of plasminogen that is encoded by the PLG gene in humans.It is produced,for example,by autoproteolytic cleavage of plasminogen,involving extracellular disulfide bond reduction by phosphoglycerate kinase.Furthermore,angiostatin can be cleaved from plasminogen by different metalloproteinases(MMPs),elastase,prostate-specific antigen(PSA),13 kDa serine protease,or 24 kDa endopeptidase.Angiostatin is known to bind many proteins,especially to angiomotin and endothelial cell surface ATP synthase but also integrins,annexin II,C-met receptor,NG2 proteoglycan,tissue-type plasminogen activator,chondroitin sulfate proteoglycans,and CD26.It seems to involve inhibition of endothelial cell migration,proliferation and induction of apoptosis,but its mechanism of action is still unclear.Angiostatin is currently undergoing clinical trials for its use in anticancer therapy.Recombinant angiostatin is expressed in E.coli..
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人Angiostatin，Angiostatin, Human，Recombinant Human Angiostatin
储存条件：冷冻（-20℃）
概述
Angiostatin,is a~30kDafragment of plasminogen that is encoded by the PLG gene in humans.It is produced,for example,by autoproteolytic cleavage of plasminogen,involving extracellular disulfide bond reduction by phosphoglycerate kinase.Furthermore,angiostatin can be cleaved from plasminogen by different metalloproteinases(MMPs),elastase,prostate-specific antigen(PSA),13 kDa serine protease,or 24 kDa endopeptidase.Angiostatin is known to bind many proteins,especially to angiomotin and endothelial cell surface ATP synthase but also integrins,annexin II,C-met receptor,NG2 proteoglycan,tissue-type plasminogen activator,chondroitin sulfate proteoglycans,and CD26.It seems to involve inhibition of endothelial cell migration,proliferation and induction of apoptosis,but its mechanism of action is still unclear.Angiostatin is currently undergoing clinical trials for its use in anticancer therapy.Recombinant angiostatin is expressed in E.coli..
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞95%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The specific activity determined by an assay on anti-proliferation and anti-migration using endothelial cells in vitro and anti-angiogenesis in vivo is 5.5×105 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in 20mMNaAc,pH 5.5,4%mannitol. |
| 内毒素 | Less than 1 EU/μg of rHuAngiostatin as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | VYLSECKTGN GKNYRGTMSK TKNGITCQKW SSTSPHRPRF SPATHPSEGL EENYCRNPDN DPQGPWCYTT DPEKRYDYCD ILECEEECMH CSGENYDGKI SKTMSGLECQ AWDSQSPHAH GYIPSKFPNK NLKKNYCRNP DRELRPWCFT TDPNKRWELC DIPRCTTPPP SSGPTYQCLK GTGENYRGNV AVTVSGHTCQ HWSAQTPHTH NRTPENFPCK NLDENYCRNP DG |
相关搜索：重组人Angiostatin，Angiostatin, Human，Recombinant Human Angiostatin